Janine M LaSalle Selected Research

Neurodevelopmental Disorders

1/2022	Placenta and fetal brain share a neurodevelopmental disorder DNA methylation profile in a mouse model of prenatal PCB exposure.
11/2019	Imprinting effects of UBE3A loss on synaptic gene networks and Wnt signaling pathways.
10/2017	Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome.
1/2017	Early motor phenotype detection in a female mouse model of Rett syndrome is improved by cross-fostering.
7/2012	Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulation.
7/2011	MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation.
2/2011	Neuronal chromatin dynamics of imprinting in development and disease.
4/2010	The role of MeCP2 in brain development and neurodevelopmental disorders.
11/2009	Imprinting regulates mammalian snoRNA-encoding chromatin decondensation and neuronal nucleolar size.
2/2009	Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism.

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Janine M LaSalle Research Topics

Disease

20	Rett Syndrome (Rett's Disorder) 01/2020 - 06/2002
18	Neurodevelopmental Disorders 01/2022 - 06/2002
13	Autistic Disorder (Autism) 01/2021 - 01/2006
9	Hepatolenticular Degeneration (Wilson's Disease) 01/2021 - 02/2013
3	Neuroblastoma 01/2021 - 02/2009
3	Liver Diseases (Liver Disease) 01/2019 - 02/2013
3	Autism Spectrum Disorder 11/2018 - 10/2009
3	Neoplasms (Cancer) 03/2016 - 09/2002
2	Down Syndrome (Down's Syndrome) 01/2021 - 01/2019
2	Fibrosis (Cirrhosis) 01/2019 - 05/2014
2	Carcinoma (Carcinomatosis) 07/2015 - 09/2002
2	Prader-Willi Syndrome (Syndrome, Prader-Willi) 10/2012 - 11/2009
1	Hypoxia (Hypoxemia) 01/2022
1	Hepatocellular Carcinoma (Hepatoma) 01/2021
1	Angelman Syndrome (Syndrome, Angelman) 11/2019
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2019
1	Cognitive Dysfunction 01/2019
1	chromosome 14 paternal Uniparental disomy 01/2018
1	Chronobiology Disorders (Circadian Rhythm Disorder) 01/2018
1	Chromosome Duplication 12/2016
1	Birth Weight (Birth Weights) 12/2016
1	Huntington Disease (Huntington's Disease) 11/2016
1	Nervous System Diseases (Neurological Disorders) 11/2016
1	Neurologic Manifestations (Neurological Manifestations) 11/2016
1	Alzheimer Disease (Alzheimer's Disease) 11/2016
1	Disease Progression 11/2016
1	Mitochondrial Diseases (Mitochondrial Disease) 11/2016
1	Inborn Genetic Diseases (Disease, Hereditary) 11/2016
1	Alcoholic Fatty Liver 06/2014
1	Body Weight (Weight, Body) 02/2014
1	Inflammation (Inflammations) 02/2013
1	Chromosome Breakage 07/2011
1	Neoplasm Metastasis (Metastasis) 09/2002

Drug/Important Bio-Agent (IBA)

17	Methyl-CpG-Binding Protein 2IBA 01/2017 - 06/2002
8	CopperIBA 01/2021 - 02/2013
7	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 01/2007
6	hydrogen sulfite (bisulfite)IBA 01/2021 - 01/2016
6	ChromatinIBA 01/2019 - 04/2008
4	Copper Transport ProteinsIBA 11/2020 - 02/2014
3	Methionine (L-Methionine)FDA Link 06/2014 - 02/2013
3	Proteins (Proteins, Gene)FDA Link 02/2009 - 04/2008
2	Polychlorinated Biphenyls (PCBs)IBA 01/2022 - 12/2016
2	Histones (Histone)IBA 01/2021 - 01/2006
2	UbiquitinIBA 11/2019 - 01/2017
2	RNA (Ribonucleic Acid)IBA 01/2019 - 11/2016
2	Folic Acid (Vitamin M)FDA LinkGeneric 01/2019 - 12/2016
2	Protein Isoforms (Isoforms)IBA 12/2018 - 10/2017
2	Biomarkers (Surrogate Marker)IBA 11/2018 - 04/2013
2	2,2',3,5',6-pentachlorobiphenylIBA 12/2016 - 10/2012
2	Choline (Choline Chloride)IBA 11/2016 - 02/2014
2	AdenosylhomocysteinaseIBA 05/2014 - 02/2013
1	Peptides (Polypeptides)IBA 01/2022
1	MethyltransferasesIBA 01/2021
1	CarbonIBA 01/2021
1	Mitochondrial DNA (mtDNA)IBA 11/2020
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2020
1	RNA Splicing FactorsIBA 01/2020
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 11/2019
1	Polycomb Repressive Complex 1IBA 01/2019
1	Cytochrome P-450 CYP2E1 (CYP2E1)IBA 01/2019
1	XenobioticsIBA 01/2019
1	ThioredoxinsIBA 11/2018
1	Peptide Hydrolases (Proteases)FDA Link 01/2017
1	Small Interfering RNA (siRNA)IBA 01/2017
1	Persistent Organic PollutantsIBA 12/2016
1	VitaminsIBA 12/2016
1	Soaps (Soap)IBA 12/2016
1	Pharmaceutical PreparationsIBA 03/2016
1	Transfer RNA (tRNA)IBA 07/2015
1	Ethanol (Ethyl Alcohol)IBA 06/2014
1	Alanine Transaminase (SGPT)IBA 02/2013
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2013
1	S-AdenosylhomocysteineIBA 02/2013
1	pentabromodiphenyl ether (PBDE)IBA 10/2012
1	Cadherins (E-Cadherin)IBA 10/2011
1	antineoplaston A10 (A 10)IBA 10/2011
1	snRNP Core ProteinsIBA 11/2009
1	Small Nucleolar RNA (snoRNA)IBA 11/2009
1	HeterochromatinIBA 01/2009
1	Trastuzumab (Herceptin)FDA Link 09/2002
1	Paclitaxel (Taxol)FDA LinkGeneric 09/2002

Therapy/Procedure

3	Therapeutics 03/2016 - 09/2002
1	Lasers (Laser) 10/2006
1	Drug Therapy (Chemotherapy) 09/2002